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Main Street Cafe & Bakery is a bakery serving Des Moines, IA, located at 801 Grand Ave Des Moines, IA 50309. Specializing in freshly baked goods, custom cakes, and pastries, Main Street Cafe & Bakery is a popular dessert destination for Des Moines residents in the Des Moines and surrounding area. Whether you're searching for artisan bread or a custom cake or a great local bakery in Des Moines, Main Street Cafe & Bakery is worth a visit.